Cytochrome c oxidase subunit 5B, mitochondrial (COX5B)

About Cytochrome c oxidase subunit 5B, mitochondrial

Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) is a protein from Homo sapiens identified by UniProt accession P10606, 129 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Cytochrome c oxidase subunit 5B, mitochondrial
UniProt accession	P10606
Gene	COX5B
Organism	Homo sapiens
Length	129 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
neuroinflammatory disorder · score 0.29
lung adenocarcinoma · score 0.19
head and neck squamous cell carcinoma · score 0.19
endometrial cancer · score 0.18
alcohol consumption measurement · score 0.08
hepatocellular carcinoma · score 0.08
breast cancer · score 0.07
neoplasm · score 0.07
smoking status measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10606-F1	alphafold	PREDICTED	84.56	—

Amino-acid sequence (129 residues)

MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE IMLAAKKGLD PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV VWFWLHKGEA QRCPRCGAHY KLVPQQLAH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards