About Microsomal glutathione S-transferase 1
Microsomal glutathione S-transferase 1 (MGST1) is a protein
from Homo sapiens identified by UniProt accession
P10620, 155 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | Microsomal glutathione S-transferase 1 |
|---|
| UniProt accession | P10620 |
|---|
| Gene | MGST1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 155 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (142)
Diseases linked to this target (Open Targets).
- esophageal adenocarcinoma · score 0.35
- Barrett's esophagus · score 0.35
- adolescent idiopathic scoliosis · score 0.33
- body fat percentage · score 0.30
- sex interaction measurement · score 0.25
- self reported educational attainment · score 0.22
- worry measurement · score 0.20
- triglyceride measurement · score 0.20
- smoking status measurement · score 0.20
- drug use measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10620-F1 | alphafold | PREDICTED | 78.73 | — |
Amino-acid sequence (155 residues)
MVDLTQVMDD EVFMAFASYA TIILSKMMLM STATAFYRLT RKVFANPEDC VAFGKGENAK KYLRTDDRVE RVRRAHLNDL ENIIPFLGIG LLYSLSGPDP STAILHFRLF VGARIYHTIA YLTPLPQPNR ALSFFVGYGV TLSMAYRLLK SKLYL
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