About cAMP-dependent protein kinase type I-alpha regulatory subunit
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) is a protein
from Homo sapiens identified by UniProt accession
P10644, 381 residues long.
MolForge cross-references it against 0 known binders and
521 disease associations.
Target properties
| Protein name | cAMP-dependent protein kinase type I-alpha regulatory subunit |
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| UniProt accession | P10644 |
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| Gene | PRKAR1A |
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| Organism | Homo sapiens |
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| Length | 381 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (521)
Diseases linked to this target (Open Targets).
- Carney complex, type 1 · score 0.79
- Acrodysostosis 1 with or without hormone resistance · score 0.76
- Carney complex · score 0.70
- acrodysostosis · score 0.67
- pigmented nodular adrenocortical disease, primary, 1 · score 0.65
- familial atrial myxoma · score 0.61
- amelogenesis imperfecta type 1G · score 0.55
- hereditary neoplastic syndrome · score 0.53
- Inherited cancer-predisposing syndrome · score 0.53
- cancer · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10644-F1 | alphafold | PREDICTED | 87.74 | — |
Amino-acid sequence (381 residues)
MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFSVSFIA GETVIQQGDE GDNFYVIDQG ETDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
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