Chromogranin-A (CHGA)

About Chromogranin-A

Chromogranin-A (CHGA) is a protein from Homo sapiens identified by UniProt accession P10645, 457 residues long. MolForge cross-references it against 0 known binders and 548 disease associations.

Target properties

Protein name	Chromogranin-A
UniProt accession	P10645
Gene	CHGA
Organism	Homo sapiens
Length	457 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (548)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.44
neurodegenerative disease · score 0.32
lung adenocarcinoma · score 0.19
squamous cell lung carcinoma · score 0.14
body height · score 0.13
head and neck squamous cell carcinoma · score 0.13
creatinine measurement · score 0.12
lymphocyte count · score 0.11
diabetes mellitus · score 0.10
coronary artery disease · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10645-F1	alphafold	PREDICTED	58.81	—

Amino-acid sequence (457 residues)

MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM PVSQECFETL RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF EDELSEVLEN QSSQAELKEA VEEPSSKDVM EKREDSKEAE KSGEATDGAR PQALPEPMQE SKAEGNNQAP GEEEEEEEEA TNTHPPASLP SQKYPGPQAE GDSEGLSQGL VDREKGLSAE PGWQAKREEE EEEEEEAEAG EEAVPEEEGP TVVLNPHPSL GYKEIRKGES RSEALAVDGA GKPGAEEAQD PEGKGEQEHS QQKEEEEEMA VVPQGLFRGG KSGELEQEEE RLSKEWEDSK RWSKMDQLAK ELTAEKRLEG QEEEEDNRDS SMKLSFRARA YGFRGPGPQL RRGWRPSSRE DSLEAGLPLQ VRGYPEEKKE EEGSANRRPE DQELESLSAI EAELEKVAHQ LQALRRG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards