About Alkaline phosphatase, germ cell type
Alkaline phosphatase, germ cell type (ALPG) is a protein
from Homo sapiens identified by UniProt accession
P10696, 532 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Alkaline phosphatase, germ cell type |
|---|
| UniProt accession | P10696 |
|---|
| Gene | ALPG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 532 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (74)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.34
- systemic lupus erythematosus · score 0.26
- refractive error measurement · score 0.23
- refractive error · score 0.22
- body height · score 0.21
- DNA methylation · score 0.16
- lean body mass · score 0.06
- hypertriglyceridemia 2 · score 0.05
- neoplasm · score 0.05
- appendicular lean mass · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10696-F1 | alphafold | PREDICTED | 92.95 | — |
Amino-acid sequence (532 residues)
MQGPWVLLLL GLRLQLSLGI IPVEEENPDF WNRQAAEALG AAKKLQPAQT AAKNLIIFLG DGMGVSTVTA ARILKGQKKD KLGPETFLAM DRFPYVALSK TYSVDKHVPD SGATATAYLC GVKGNFQTIG LSAAARFNQC NTTRGNEVIS VMNRAKKAGK SVGVVTTTRV QHASPAGAYA HTVNRNWYSD ADVPASARQE GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPDDY SQGGTRLDGK NLVQEWLAKH QGARYVWNRT ELLQASLDPS VTHLMGLFEP GDMKYEIHRD STLDPSLMEM TEAALLLLSR NPRGFFLFVE GGRIDHGHHE SRAYRALTET IMFDDAIERA GQLTSEEDTL SLVTADHSHV FSFGGYPLRG SSIFGLAPGK ARDRKAYTVL LYGNGPGYVL KDGARPDVTE SESGSPEYRQ QSAVPLDGET HAGEDVAVFA RGPQAHLVHG VQEQTFIAHV MAFAACLEPY TACDLAPRAG TTDAAHPGPS VVPALLPLLA GTLLLLGTAT AP
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