About Uroporphyrinogen-III synthase
Uroporphyrinogen-III synthase (UROS) is a protein
from Homo sapiens identified by UniProt accession
P10746, 265 residues long.
MolForge cross-references it against 0 known binders and
157 disease associations.
Target properties
| Protein name | Uroporphyrinogen-III synthase |
|---|
| UniProt accession | P10746 |
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| Gene | UROS |
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| Organism | Homo sapiens |
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| Length | 265 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (157)
Diseases linked to this target (Open Targets).
- Congenital erythropoietic porphyria · score 0.85
- cutaneous porphyria · score 0.79
- neurodegenerative disease · score 0.43
- blood protein measurement · score 0.32
- appendicular lean mass · score 0.26
- Red cell distribution width · score 0.21
- genetic disorder · score 0.17
- erythrocyte count · score 0.15
- mean corpuscular volume · score 0.14
- mean corpuscular hemoglobin · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10746-F1 | alphafold | PREDICTED | 93.12 | — |
Amino-acid sequence (265 residues)
MKVLLLKDAK EDDCGQDPYI RELGLYGLEA TLIPVLSFEF LSLPSFSEKL SHPEDYGGLI FTSPRAVEAA ELCLEQNNKT EVWERSLKEK WNAKSVYVVG NATASLVSKI GLDTEGETCG NAEKLAEYIC SRESSALPLL FPCGNLKREI LPKALKDKGI AMESITVYQT VAHPGIQGNL NSYYSQQGVP ASITFFSPSG LTYSLKHIQE LSGDNIDQIK FAAIGPTTAR ALAAQGLPVS CTAESPTPQA LATGIRKALQ PHGCC
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