About T-cell-specific surface glycoprotein CD28
T-cell-specific surface glycoprotein CD28 (CD28) is a protein
from Homo sapiens identified by UniProt accession
P10747, 220 residues long.
MolForge cross-references it against 0 known binders and
883 disease associations.
Target properties
| Protein name | T-cell-specific surface glycoprotein CD28 |
|---|
| UniProt accession | P10747 |
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| Gene | CD28 |
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| Organism | Homo sapiens |
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| Length | 220 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (883)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.51
- blood protein measurement · score 0.49
- eosinophil count · score 0.49
- rheumatoid arthritis · score 0.46
- lymphocyte count · score 0.41
- celiac disease · score 0.41
- eosinophil percentage of leukocytes · score 0.40
- cancer · score 0.39
- asthma · score 0.39
- sclerosing cholangitis · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10747-F1 | alphafold | PREDICTED | 81.31 | — |
Amino-acid sequence (220 residues)
MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS
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