S-formylglutathione hydrolase (ESD)

About S-formylglutathione hydrolase

S-formylglutathione hydrolase (ESD) is a protein from Homo sapiens identified by UniProt accession P10768, 282 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	S-formylglutathione hydrolase
UniProt accession	P10768
Gene	ESD
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

neuroinflammatory disorder · score 0.37
S-formylglutathione hydrolase measurement · score 0.35
protein measurement · score 0.32
blood protein measurement · score 0.32
cerebrospinal fluid biomarker measurement · score 0.32
platelet component distribution width · score 0.15
metabolite measurement · score 0.15
systolic blood pressure · score 0.14
bone density · score 0.12
urate measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10768-F1	alphafold	PREDICTED	98.23	—

Amino-acid sequence (282 residues)

MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW LSGLTCTEQN FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG TGAGFYVDAT EDPWKTNYRM YSYVTEELPQ LINANFPVDP QRMSIFGHSM GGHGALICAL KNPGKYKSVS AFAPICNPVL CPWGKKAFSG YLGTDQSKWK AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI AACTEKKIPV VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards