About 60 kDa heat shock protein, mitochondrial
60 kDa heat shock protein, mitochondrial (HSPD1) is a protein
from Homo sapiens identified by UniProt accession
P10809, 573 residues long.
MolForge cross-references it against 0 known binders and
587 disease associations.
Target properties
| Protein name | 60 kDa heat shock protein, mitochondrial |
|---|
| UniProt accession | P10809 |
|---|
| Gene | HSPD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 573 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (587)
Diseases linked to this target (Open Targets).
- hypomyelinating leukodystrophy 4 · score 0.75
- Autosomal dominant spastic paraplegia type 13 · score 0.74
- Pelizaeus-Merzbacher-like disease due to HSPD1 mutation · score 0.74
- hereditary spastic paraplegia 13 · score 0.70
- neurodegenerative disease · score 0.56
- schizophrenia · score 0.20
- Spastic paraplegia · score 0.20
- hereditary spastic paraplegia · score 0.20
- genetic disorder · score 0.18
- cortical thickness · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10809-F1 | alphafold | PREDICTED | 88.13 | — |
Amino-acid sequence (573 residues)
MLRLPTVFRQ MRPVSRVLAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ DAYVLLSEKK ISSIQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL TLNLEDVQPH DLGKVGEVIV TKDDAMLLKG KGDKAQIEKR IQEIIEQLDV TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR VTDALNATRA AVEEGIVLGG GCALLRCIPA LDSLTPANED QKIGIEIIKR TLKIPAMTIA KNAGVEGSLI VEKIMQSSSE VGYDAMAGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT TAEVVVTEIP KEEKDPGMGA MGGMGGGMGG GMF
Explore 60 kDa heat shock protein, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets