About Clusterin
Clusterin (CLU) is a protein
from Homo sapiens identified by UniProt accession
P10909, 449 residues long.
MolForge cross-references it against 0 known binders and
727 disease associations.
Target properties
| Protein name | Clusterin |
|---|
| UniProt accession | P10909 |
|---|
| Gene | CLU |
|---|
| Organism | Homo sapiens |
|---|
| Length | 449 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (727)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.44
- family history of Alzheimer’s disease · score 0.41
- prostate cancer · score 0.36
- late-onset Alzheimers disease · score 0.35
- Myopia · score 0.28
- Abnormality of refraction · score 0.28
- non-small cell lung carcinoma · score 0.28
- age at onset · score 0.28
- refractive error · score 0.28
- fasting blood insulin measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10909-F1 | alphafold | PREDICTED | 77.31 | — |
Amino-acid sequence (449 residues)
MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP VEVSRKNPKF METVAEKALQ EYRKKHREE
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