About Growth hormone receptor
Growth hormone receptor (GHR) is a protein
from Homo sapiens identified by UniProt accession
P10912, 638 residues long.
MolForge cross-references it against 0 known binders and
557 disease associations.
Target properties
| Protein name | Growth hormone receptor |
|---|
| UniProt accession | P10912 |
|---|
| Gene | GHR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 638 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (557)
Diseases linked to this target (Open Targets).
- Laron syndrome · score 0.81
- short stature due to partial GHR deficiency · score 0.75
- Short stature · score 0.64
- pituitary dwarfism · score 0.60
- Turner syndrome · score 0.60
- acromegaly · score 0.59
- fetal growth restriction · score 0.58
- Prader-Willi syndrome · score 0.56
- Growth delay · score 0.56
- chronic kidney disease · score 0.54
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10912-F1 | alphafold | PREDICTED | 58.70 | — |
Amino-acid sequence (638 residues)
MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE PKFTKCRSPE RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSFTS IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD PPIALNWTLL NVSLTGIHAD IQVRWEAPRN ADIQKGWMVL EYELQYKEVN ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY GEFSEVLYVT LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRIKMLILPP VPVPKIKGID PDLLKEGKLE EVNTILAIHD SYKPEFHSDD SWVEFIELDI DEPDEKTEES DTDRLLSSDH EKSHSNLGVK DGDSGRTSCC EPDILETDFN ANDIHEGTSE VAQPQRLKGE ADLLCLDQKN QNNSPYHDAC PATQQPSVIQ AEKNKPQPLP TEGAESTHQA AHIQLSNPSS LSNIDFYAQV SDITPAGSVV LSPGQKNKAG MSQCDMHPEM VSLCQENFLM DNAYFCEADA KKCIPVAPHI KVESHIQPSL NQEDIYITTE SLTTAAGRPG TGEHVPGSEM PVPDYTSIHI VQSPQGLILN ATALPLPDKE FLSSCGYVST DQLNKIMP
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