About Interferon regulatory factor 1
Interferon regulatory factor 1 (IRF1) is a protein
from Homo sapiens identified by UniProt accession
P10914, 325 residues long.
MolForge cross-references it against 0 known binders and
639 disease associations.
Target properties
| Protein name | Interferon regulatory factor 1 |
|---|
| UniProt accession | P10914 |
|---|
| Gene | IRF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 325 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (639)
Diseases linked to this target (Open Targets).
- gastric cancer · score 0.59
- gastric carcinoma · score 0.55
- platelet count · score 0.42
- neurodegenerative disease · score 0.41
- neutrophil count · score 0.40
- Crohn's disease · score 0.39
- asthma · score 0.39
- cystatin C measurement · score 0.38
- eosinophil count · score 0.37
- neuroinflammatory disorder · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10914-F1 | alphafold | PREDICTED | 65.72 | — |
Amino-acid sequence (325 residues)
MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPPLTKNQR KERKSKSSRD AKSKAKRKSC GDSSPDTFSD GLSSSTLPDD HSSYTVPGYM QDLEVEQALT PALSPCAVSS TLPDWHIPVE VVPDSTSDLY NFQVSPMPST SEATTDEDEE GKLPEDIMKL LEQSEWQPTN VDGKGYLLNE PGVQPTSVYG DFSCKEEPEI DSPGGDIGLS LQRVFTDLKN MDATWLDSLL TPVRLPSIQA IPCAP
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