Hyaluronan and proteoglycan link protein 1 (HAPLN1)

About Hyaluronan and proteoglycan link protein 1

Hyaluronan and proteoglycan link protein 1 (HAPLN1) is a protein from Homo sapiens identified by UniProt accession P10915, 354 residues long. MolForge cross-references it against 0 known binders and 236 disease associations.

Target properties

Protein name	Hyaluronan and proteoglycan link protein 1
UniProt accession	P10915
Gene	HAPLN1
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (236)

Diseases linked to this target (Open Targets).

white matter microstructure measurement · score 0.44
peak expiratory flow · score 0.36
FEV/FVC ratio · score 0.28
breast adenocarcinoma · score 0.20
triglyceride measurement · score 0.19
gestational diabetes · score 0.16
cerebrospinal fluid biomarker measurement · score 0.14
ankylosing spondylitis · score 0.14
neoplasm · score 0.10
Miyoshi myopathy · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10915-F1	alphafold	PREDICTED	89.51	—

Amino-acid sequence (354 residues)

MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF SHRGGNVTLP CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY HKKTYGGYQG RVFLKGGSDS DASLVITDLT LEDYGRYKCE VIEGLEDDTV VVALDLQGVV FPYFPRLGRY NLNFHEAQQA CLDQDAVIAS FDQLYDAWRG GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF WDKDKSRYDV FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF RAYN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards