T-cell surface glycoprotein CD8 beta chain (CD8B)

About T-cell surface glycoprotein CD8 beta chain

T-cell surface glycoprotein CD8 beta chain (CD8B) is a protein from Homo sapiens identified by UniProt accession P10966, 210 residues long. MolForge cross-references it against 0 known binders and 197 disease associations.

Target properties

Protein name	T-cell surface glycoprotein CD8 beta chain
UniProt accession	P10966
Gene	CD8B
Organism	Homo sapiens
Length	210 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (197)

Diseases linked to this target (Open Targets).

HIV infection · score 0.50
blood protein measurement · score 0.45
lymphocyte count · score 0.36
progressive supranuclear palsy · score 0.10
leukocyte count · score 0.09
Okt4 epitope deficiency · score 0.08
neoplasm · score 0.07
combined immunodeficiency with skin granulomas · score 0.07
severe combined immunodeficiency due to IKK2 deficiency · score 0.07
severe combined immunodeficiency due to CARD11 deficiency · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10966-F1	alphafold	PREDICTED	82.03	—

Amino-acid sequence (210 residues)

MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV LVLLVSLGVA IHLCCRRRRA RLRFMKQFYK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards