Islet amyloid polypeptide (IAPP)

About Islet amyloid polypeptide

Islet amyloid polypeptide (IAPP) is a protein from Homo sapiens identified by UniProt accession P10997, 89 residues long. MolForge cross-references it against 0 known binders and 328 disease associations.

Target properties

Protein name	Islet amyloid polypeptide
UniProt accession	P10997
Gene	IAPP
Organism	Homo sapiens
Length	89 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (328)

Diseases linked to this target (Open Targets).

AL amyloidosis · score 0.46
response to neuromuscular blocker · score 0.24
blood protein measurement · score 0.22
lean body mass · score 0.12
breast adenocarcinoma · score 0.10
cortical thickness · score 0.10
bilirubin measurement · score 0.10
fat body mass · score 0.10
type 2 diabetes mellitus · score 0.10
diabetes mellitus · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10997-F1	alphafold	PREDICTED	78.33	—

Amino-acid sequence (89 residues)

MGILKLQVFL IVLSVALNHL KATPIESHQV EKRKCNTATC ATQRLANFLV HSSNNFGAIL SSTNVGSNTY GKRNAVEVLK REPLNYLPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards