Phenylethanolamine N-methyltransferase (PNMT)

About Phenylethanolamine N-methyltransferase

Phenylethanolamine N-methyltransferase (PNMT) is a protein from Homo sapiens identified by UniProt accession P11086, 282 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.

Target properties

Protein name	Phenylethanolamine N-methyltransferase
UniProt accession	P11086
Gene	PNMT
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (126)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.27
sleep duration · score 0.21
cutaneous melanoma · score 0.19
alcohol consumption measurement · score 0.13
alkaline phosphatase measurement · score 0.13
neurodegenerative disease · score 0.13
self reported educational attainment · score 0.13
age at menopause · score 0.11
total cholesterol measurement · score 0.11
physical activity · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11086-F1	alphafold	PREDICTED	93.92	—

Amino-acid sequence (282 residues)

MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards