Lysosomal acid phosphatase (ACP2)

About Lysosomal acid phosphatase

Lysosomal acid phosphatase (ACP2) is a protein from Homo sapiens identified by UniProt accession P11117, 423 residues long. MolForge cross-references it against 0 known binders and 261 disease associations.

Target properties

Protein name	Lysosomal acid phosphatase
UniProt accession	P11117
Gene	ACP2
Organism	Homo sapiens
Length	423 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (261)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.32
triglyceride measurement · score 0.27
sleep duration · score 0.25
C-reactive protein measurement · score 0.23
serum urea measurement · score 0.21
IGF-1 measurement · score 0.21
HDL cholesterol change measurement · score 0.20
physical activity · score 0.20
neurodegenerative disease · score 0.20
apolipoprotein A 1 measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11117-F1	alphafold	PREDICTED	91.63	—

Amino-acid sequence (423 residues)

MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR LLKFPLGPCP RYEQLQNETR QTPEYQNESS RNAQFLDMVA NETGLTDLTL ETVWNVYDTL FCEQTHGLRL PPWASPQTMQ RLSRLKDFSF RFLFGIYQQA EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY NGEQAPYASC HIFELYQEDS GNFSVEMYFR NESDKAPWPL SLPGCPHRCP LQDFLRLTEP VVPKDWQQEC QLASGPADTE VIVALAVCGS ILFLLIVLLL TVLFRMQAQP PGYRHVADGE DHA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards