About Hepatic triacylglycerol lipase
Hepatic triacylglycerol lipase (LIPC) is a protein
from Homo sapiens identified by UniProt accession
P11150, 499 residues long.
MolForge cross-references it against 0 known binders and
359 disease associations.
Target properties
| Protein name | Hepatic triacylglycerol lipase |
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| UniProt accession | P11150 |
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| Gene | LIPC |
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| Organism | Homo sapiens |
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| Length | 499 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (359)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.72
- lipoprotein measurement · score 0.67
- hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.64
- triglyceride measurement · score 0.63
- high density lipoprotein particle size measurement · score 0.62
- total cholesterol measurement · score 0.61
- phospholipids:total lipids ratio · score 0.59
- cholesteryl ester measurement · score 0.59
- concentration of large HDL particles measurement · score 0.58
- phospholipid measurement · score 0.57
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11150-F1 | alphafold | PREDICTED | 82.06 | — |
Amino-acid sequence (499 residues)
MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK VYHYQFKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL KTIRVKAGET QQRMTFCSEN TDDLLLRPTQ EKIFVKCEIK SKTSKRKIR
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