About Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT) is a protein
from Homo sapiens identified by UniProt accession
P11182, 482 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial |
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| UniProt accession | P11182 |
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| Gene | DBT |
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| Organism | Homo sapiens |
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| Length | 482 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (107)
Diseases linked to this target (Open Targets).
- maple syrup urine disease · score 0.71
- maple syrup urine disease type 1A · score 0.69
- convulsion · score 0.37
- intermittent maple syrup urine disease · score 0.37
- classic maple syrup urine disease · score 0.37
- intermediate maple syrup urine disease · score 0.37
- thiamine-responsive maple syrup urine disease · score 0.37
- Seizure · score 0.37
- genetic disorder · score 0.19
- nonpapillary renal cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11182-F1 | alphafold | PREDICTED | 78.90 | — |
Amino-acid sequence (482 residues)
MAAVRMLRTW SRNAGKLICV RYFQTCGNVH VLKPNYVCFF GYPSFKYSHP HHFLKTTAAL RGQVVQFKLS DIGEGIREVT VKEWYVKEGD TVSQFDSICE VQSDKASVTI TSRYDGVIKK LYYNLDDIAY VGKPLVDIET EALKDSEEDV VETPAVSHDE HTHQEIKGRK TLATPAVRRL AMENNIKLSE VVGSGKDGRI LKEDILNYLE KQTGAILPPS PKVEIMPPPP KPKDMTVPIL VSKPPVFTGK DKTEPIKGFQ KAMVKTMSAA LKIPHFGYCD EIDLTELVKL REELKPIAFA RGIKLSFMPF FLKAASLGLL QFPILNASVD ENCQNITYKA SHNIGIAMDT EQGLIVPNVK NVQICSIFDI ATELNRLQKL GSVSQLSTTD LTGGTFTLSN IGSIGGTFAK PVIMPPEVAI GALGSIKAIP RFNQKGEVYK AQIMNVSWSA DHRVIDGATM SRFSNLWKSY LENPAFMLLD LK
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