Acetylcholine receptor subunit beta (CHRNB1)

About Acetylcholine receptor subunit beta

Acetylcholine receptor subunit beta (CHRNB1) is a protein from Homo sapiens identified by UniProt accession P11230, 501 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Acetylcholine receptor subunit beta
UniProt accession	P11230
Gene	CHRNB1
Organism	Homo sapiens
Length	501 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

Congenital myasthenic syndromes · score 0.79
post-operative sign or symptom · score 0.58
pain · score 0.55
acute respiratory distress syndrome · score 0.53
pregnancy · score 0.50
severe acute respiratory syndrome · score 0.50
intracranial hypertension · score 0.46
rotator cuff tear · score 0.46
morbid obesity · score 0.46
oxidative stress · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11230-F1	alphafold	PREDICTED	79.46	—

Amino-acid sequence (501 residues)

MTPGALLMLL GALGAPLAPG VRGSEAEGRL REKLFSGYDS SVRPAREVGD RVRVSVGLIL AQLISLNEKD EEMSTKVYLD LEWTDYRLSW DPAEHDGIDS LRITAESVWL PDVVLLNNND GNFDVALDIS VVVSSDGSVR WQPPGIYRSS CSIQVTYFPF DWQNCTMVFS SYSYDSSEVS LQTGLGPDGQ GHQEIHIHEG TFIENGQWEI IHKPSRLIQP PGDPRGGREG QRQEVIFYLI IRRKPLFYLV NVIAPCILIT LLAIFVFYLP PDAGEKMGLS IFALLTLTVF LLLLADKVPE TSLSVPIIIK YLMFTMVLVT FSVILSVVVL NLHHRSPHTH QMPLWVRQIF IHKLPLYLRL KRPKPERDLM PEPPHCSSPG SGWGRGTDEY FIRKPPSDFL FPKPNRFQPE LSAPDLRRFI DGPNRAVALL PELREVVSSI SYIARQLQEQ EDHDALKEDW QFVAMVVDRL FLWTFIIFTS VGTLVIFLDA TYHLPPPDPF P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards