Arylamine N-acetyltransferase 2 (NAT2)

About Arylamine N-acetyltransferase 2

Arylamine N-acetyltransferase 2 (NAT2) is a protein from Homo sapiens identified by UniProt accession P11245, 290 residues long. MolForge cross-references it against 0 known binders and 221 disease associations.

Target properties

Protein name	Arylamine N-acetyltransferase 2
UniProt accession	P11245
Gene	NAT2
Organism	Homo sapiens
Length	290 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (221)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.47
total cholesterol measurement · score 0.46
urinary metabolite measurement · score 0.44
serum metabolite measurement · score 0.42
blood metabolite measurement · score 0.41
mean corpuscular hemoglobin concentration · score 0.41
low density lipoprotein cholesterol measurement · score 0.41
serum albumin measurement · score 0.40
coronary artery disease · score 0.39
urinary bladder carcinoma · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11245-F1	alphafold	PREDICTED	96.46	—

Amino-acid sequence (290 residues)

MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT DLVEFKTLTE EEVEEVLRNI FKISLGRNLV PKPGDGSLTI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards