Lysosome-associated membrane glycoprotein 1 (LAMP1)

About Lysosome-associated membrane glycoprotein 1

Lysosome-associated membrane glycoprotein 1 (LAMP1) is a protein from Homo sapiens identified by UniProt accession P11279, 417 residues long. MolForge cross-references it against 0 known binders and 435 disease associations.

Target properties

Protein name	Lysosome-associated membrane glycoprotein 1
UniProt accession	P11279
Gene	LAMP1
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (435)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.24
neutrophil count · score 0.14
leukocyte count · score 0.14
C-reactive protein measurement · score 0.13
myeloid white cell count · score 0.11
apolipoprotein A 1 measurement · score 0.10
infection · score 0.10
infect · score 0.10
breast cancer · score 0.08
cholangiocarcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11279-F1	alphafold	PREDICTED	86.43	—

Amino-acid sequence (417 residues)

MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY NLSDTHLFPN ASSKEIKTVE SITDIRADID KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS NSSFSRGETR CEQDRPSPTT APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL NLTYERKDNT TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF SVNIFKVWVQ AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL IAYLVGRKRS HAGYQTI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards