Transcriptional regulator ERG (ERG)

About Transcriptional regulator ERG

Transcriptional regulator ERG (ERG) is a protein from Homo sapiens identified by UniProt accession P11308, 479 residues long. MolForge cross-references it against 0 known binders and 393 disease associations.

Target properties

Protein name	Transcriptional regulator ERG
UniProt accession	P11308
Gene	ERG
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (393)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.51
erythrocyte count · score 0.50
basophil count · score 0.50
refractive error measurement · score 0.50
monocyte count · score 0.50
platelet count · score 0.50
leukocyte count · score 0.49
eosinophil count · score 0.49
mean corpuscular hemoglobin · score 0.48
neutrophil count · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11308-F1	alphafold	PREDICTED	59.36	—

Amino-acid sequence (479 residues)

MASTIKEALS VVSEDQSLFE CAYGTPHLAK TEMTASSSSD YGQTSKMSPR VPQQDWLSQP PARVTIKMEC NPSQVNGSRN SPDECSVAKG GKMVGSPDTV GMNYGSYMEE KHMPPPNMTT NERRVIVPAD PTLWSTDHVR QWLEWAVKEY GLPDVNILLF QNIDGKELCK MTKDDFQRLT PSYNADILLS HLHYLRETPL PHLTSDDVDK ALQNSPRLMH ARNTGGAAFI FPNTSVYPEA TQRITTRPDL PYEPPRRSAW TGHGHPTPQS KAAQPSPSTV PKTEDQRPQL DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSSNSSCI TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK VHGKRYAYKF DFHGIAQALQ PHPPESSLYK YPSDLPYMGS YHAHPQKMNF VAPHPPALPV TSSSFFAAPN PYWNSPTGGI YPNTRLPTSH MPSHLGTYY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards