About Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) is a protein
from Homo sapiens identified by UniProt accession
P11310, 421 residues long.
MolForge cross-references it against 0 known binders and
190 disease associations.
Target properties
| Protein name | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
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| UniProt accession | P11310 |
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| Gene | ACADM |
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| Organism | Homo sapiens |
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| Length | 421 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (190)
Diseases linked to this target (Open Targets).
- medium chain acyl-CoA dehydrogenase deficiency · score 0.85
- genetic disorder · score 0.49
- Abnormal circulating lipid concentration · score 0.41
- serum metabolite measurement · score 0.39
- blood metabolite measurement · score 0.37
- blood protein measurement · score 0.37
- rhabdomyolysis · score 0.37
- urinary metabolite measurement · score 0.36
- Epileptic spasm · score 0.33
- acylcarnitine measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11310-F1 | alphafold | PREDICTED | 93.40 | — |
Amino-acid sequence (421 residues)
MAAGFGRCCR VLRSISRFHW RSQHTKANRQ REPGLGFSFE FTEQQKEFQA TARKFAREEI IPVAAEYDKT GEYPVPLIRR AWELGLMNTH IPENCGGLGL GTFDACLISE ELAYGCTGVQ TAIEGNSLGQ MPIIIAGNDQ QKKKYLGRMT EEPLMCAYCV TEPGAGSDVA GIKTKAEKKG DEYIINGQKM WITNGGKANW YFLLARSDPD PKAPANKAFT GFIVEADTPG IQIGRKELNM GQRCSDTRGI VFEDVKVPKE NVLIGDGAGF KVAMGAFDKT RPVVAAGAVG LAQRALDEAT KYALERKTFG KLLVEHQAIS FMLAEMAMKV ELARMSYQRA AWEVDSGRRN TYYASIAKAF AGDIANQLAT DAVQILGGNG FNTEYPVEKL MRDAKIYQIY EGTSQIQRLI VAREHIDKYK N
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