Pregnancy-specific beta-1-glycoprotein 1 (PSG1)

About Pregnancy-specific beta-1-glycoprotein 1

Pregnancy-specific beta-1-glycoprotein 1 (PSG1) is a protein from Homo sapiens identified by UniProt accession P11464, 419 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Pregnancy-specific beta-1-glycoprotein 1
UniProt accession	P11464
Gene	PSG1
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.29
visual perception measurement · score 0.21
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.11
low grade glioma · score 0.10
obesity due to melanocortin 4 receptor deficiency · score 0.06
birth weight · score 0.05
LIPE-related familial partial lipodystrophy · score 0.04
obesity due to leptin receptor gene deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11464-F1	alphafold	PREDICTED	86.33	—

Amino-acid sequence (419 residues)

MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA TGKESSKSMT VEVSDWTVP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards