Steroid hormone receptor ERR1 (ESRRA)

About Steroid hormone receptor ERR1

Steroid hormone receptor ERR1 (ESRRA) is a protein from Homo sapiens identified by UniProt accession P11474, 423 residues long. MolForge cross-references it against 0 known binders and 243 disease associations.

Target properties

Protein name	Steroid hormone receptor ERR1
UniProt accession	P11474
Gene	ESRRA
Organism	Homo sapiens
Length	423 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (243)

Diseases linked to this target (Open Targets).

adenoid cystic carcinoma · score 0.18
breast cancer · score 0.11
triple-negative breast cancer · score 0.11
neoplasm · score 0.11
osteosarcoma · score 0.10
cancer · score 0.08
non-alcoholic fatty liver disease · score 0.08
oral squamous cell carcinoma · score 0.08
non-small cell lung carcinoma · score 0.08
lung adenocarcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11474-F1	alphafold	PREDICTED	77.01	—

Amino-acid sequence (423 residues)

MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH KEEEDGEGAG PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP LAVAGGPRKT AAPVNALVSH LLVVEPEKLY AMPDPAGPDG HLPAVATLCD LFDREIVVTI SWAKSIPGFS SLSLSDQMSV LQSVWMEVLV LGVAQRSLPL QDELAFAEDL VLDEEGARAA GLGELGAALL QLVRRLQALR LEREEYVLLK ALALANSDSV HIEDAEAVEQ LREALHEALL EYEAGRAGPG GGAERRRAGR LLLTLPLLRQ TAGKVLAHFY GVKLEGKVPM HKLFLEMLEA MMD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards