About Fibroblast growth factor 3
Fibroblast growth factor 3 (FGF3) is a protein
from Homo sapiens identified by UniProt accession
P11487, 239 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Fibroblast growth factor 3 |
|---|
| UniProt accession | P11487 |
|---|
| Gene | FGF3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 239 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (186)
Diseases linked to this target (Open Targets).
- deafness with labyrinthine aplasia, microtia, and microdontia · score 0.77
- cancer · score 0.59
- bone development disease · score 0.57
- female reproductive endometrioid cancer · score 0.46
- ovarian carcinoma · score 0.37
- hearing loss · score 0.37
- breast adenocarcinoma · score 0.35
- lung adenocarcinoma · score 0.29
- cutaneous melanoma · score 0.29
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11487-F1 | alphafold | PREDICTED | 78.32 | — |
Amino-acid sequence (239 residues)
MGLIWLLLLS LLEPGWPAAG PGARLRRDAG GRGGVYEHLG GAPRRRKLYC ATKYHLQLHP SGRVNGSLEN SAYSILEITA VEVGIVAIRG LFSGRYLAMN KRGRLYASEH YSAECEFVER IHELGYNTYA SRLYRTVSST PGARRQPSAE RLWYVSVNGK GRPRRGFKTR RTQKSSLFLP RVLDHRDHEM VRQLQSGLPR PPGKGVQPRR RRQKQSPDNL EPSHVQASRL GSQLEASAH
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