About Cytochrome P450 2A6
Cytochrome P450 2A6 (CYP2A6) is a protein
from Homo sapiens identified by UniProt accession
P11509, 494 residues long.
MolForge cross-references it against 0 known binders and
179 disease associations.
Target properties
| Protein name | Cytochrome P450 2A6 |
|---|
| UniProt accession | P11509 |
|---|
| Gene | CYP2A6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 494 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (179)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.40
- nicotine metabolite ratio · score 0.38
- smoking behavior · score 0.37
- cigarettes per day measurement · score 0.37
- low density lipoprotein cholesterol measurement · score 0.35
- smoking cessation · score 0.35
- serum alanine aminotransferase measurement · score 0.33
- coffee consumption measurement · score 0.33
- cholesterol embolism · score 0.33
- lung carcinoma · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11509-F1 | alphafold | PREDICTED | 96.58 | — |
Amino-acid sequence (494 residues)
MLASGMLLVA LLVCLTVMVL MSVWQQRKSK GKLPPGPTPL PFIGNYLQLN TEQMYNSLMK ISERYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG RGEQATFDWV FKGYGVVFSN GERAKQLRRF SIATLRDFGV GKRGIEERIQ EEAGFLIDAL RGTGGANIDP TFFLSRTVSN VISSIVFGDR FDYKDKEFLS LLRMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFQL LQGLEDFIAK KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFI GGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VYPMLGSVLR DPSFFSNPQD FNPQHFLNEK GQFKKSDAFV PFSIGKRNCF GEGLARMELF LFFTTVMQNF RLKSSQSPKD IDVSPKHVGF ATIPRNYTMS FLPR
Explore Cytochrome P450 2A6 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets