C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)

About C-1-tetrahydrofolate synthase, cytoplasmic

C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) is a protein from Homo sapiens identified by UniProt accession P11586, 935 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.

Target properties

Protein name	C-1-tetrahydrofolate synthase, cytoplasmic
UniProt accession	P11586
Gene	MTHFD1
Organism	Homo sapiens
Length	935 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (171)

Diseases linked to this target (Open Targets).

combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia · score 0.76
severe combined immunodeficiency · score 0.47
colorectal neoplasm · score 0.37
colorectal adenocarcinoma · score 0.37
colorectal cancer · score 0.37
appendicular lean mass · score 0.19
genetic disorder · score 0.19
testosterone measurement · score 0.18
isolated spina bifida · score 0.18
heel bone mineral density · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11586-F1	alphafold	PREDICTED	94.57	—

Amino-acid sequence (935 residues)

MAPAEILNGK EISAQIRARL KNQVTQLKEQ VPGFTPRLAI LQVGNRDDSN LYINVKLKAA EEIGIKATHI KLPRTTTESE VMKYITSLNE DSTVHGFLVQ LPLDSENSIN TEEVINAIAP EKDVDGLTSI NAGKLARGDL NDCFIPCTPK GCLELIKETG VPIAGRHAVV VGRSKIVGAP MHDLLLWNNA TVTTCHSKTA HLDEEVNKGD ILVVATGQPE MVKGEWIKPG AIVIDCGINY VPDDKKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLEKFKP GKWMIQYNNL NLKTPVPSDI DISRSCKPKP IGKLAREIGL LSEEVELYGE TKAKVLLSAL ERLKHRPDGK YVVVTGITPT PLGEGKSTTT IGLVQALGAH LYQNVFACVR QPSQGPTFGI KGGAAGGGYS QVIPMEEFNL HLTGDIHAIT AANNLVAAAI DARIFHELTQ TDKALFNRLV PSVNGVRRFS DIQIRRLKRL GIEKTDPTTL TDEEINRFAR LDIDPETITW QRVLDTNDRF LRKITIGQAP TEKGHTRTAQ FDISVASEIM AVLALTTSLE DMRERLGKMV VASSKKGEPV SAEDLGVSGA LTVLMKDAIK PNLMQTLEGT PVFVHAGPFA NIAHGNSSII ADRIALKLVG PEGFVVTEAG FGADIGMEKF FNIKCRYSGL CPHVVVLVAT VRALKMHGGG PTVTAGLPLP KAYIQENLEL VEKGFSNLKK QIENARMFGI PVVVAVNAFK TDTESELDLI SRLSREHGAF DAVKCTHWAE GGKGALALAQ AVQRAAQAPS SFQLLYDLKL PVEDKIRIIA QKIYGADDIE LLPEAQHKAE VYTKQGFGNL PICMAKTHLS LSHNPEQKGV PTGFILPIRD IRASVGAGFL YPLVGTMSTM PGLPTRPCFY DIDLDPETEQ VNGLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards