About Cholesteryl ester transfer protein
Cholesteryl ester transfer protein (CETP) is a protein
from Homo sapiens identified by UniProt accession
P11597, 493 residues long.
MolForge cross-references it against 0 known binders and
369 disease associations.
Target properties
| Protein name | Cholesteryl ester transfer protein |
|---|
| UniProt accession | P11597 |
|---|
| Gene | CETP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 493 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (369)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.71
- cholesterol-ester transfer protein deficiency · score 0.69
- lipoprotein measurement · score 0.66
- cholesteryl ester measurement · score 0.58
- concentration of large HDL particles measurement · score 0.57
- high density lipoprotein particle size measurement · score 0.55
- total lipids in large HDL · score 0.55
- free cholesterol to total lipids in very large HDL percentage · score 0.55
- cholesterol to total lipids in medium HDL percentage · score 0.54
- cholesterol in large HDL measurement · score 0.54
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11597-F1 | alphafold | PREDICTED | 91.15 | — |
Amino-acid sequence (493 residues)
MLAATVLTLA LLGNAHACSK GTSHEAGIVC RITKPALLVL NHETAKVIQT AFQRASYPDI TGEKAMMLLG QVKYGLHNIQ ISHLSIASSQ VELVEAKSID VSIQNVSVVF KGTLKYGYTT AWWLGIDQSI DFEIDSAIDL QINTQLTCDS GRVRTDAPDC YLSFHKLLLH LQGEREPGWI KQLFTNFISF TLKLVLKGQI CKEINVISNI MADFVQTRAA SILSDGDIGV DISLTGDPVI TASYLESHHK GHFIYKNVSE DLPLPTFSPT LLGDSRMLYF WFSERVFHSL AKVAFQDGRL MLSLMGDEFK AVLETWGFNT NQEIFQEVVG GFPSQAQVTV HCLKMPKISC QNKGVVVNSS VMVKFLFPRP DQQHSVAYTF EEDIVTTVQA SYSKKKLFLS LLDFQITPKT VSNLTESSSE SVQSFLQSMI TAVGIPEVMS RLEVVFTALM NSKGVSLFDI INPEIITRDG FLLLQMDFGF PEHLLVDFLQ SLS
Explore Cholesteryl ester transfer protein with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets