About Surfactant protein C
Surfactant protein C (SFTPC) is a protein
from Homo sapiens identified by UniProt accession
P11686, 197 residues long.
MolForge cross-references it against 0 known binders and
184 disease associations.
Target properties
| Protein name | Surfactant protein C |
|---|
| UniProt accession | P11686 |
|---|
| Gene | SFTPC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 197 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (184)
Diseases linked to this target (Open Targets).
- chronic respiratory distress with surfactant metabolism deficiency · score 0.71
- Congenital pulmonary alveolar proteinosis · score 0.68
- hereditary pulmonary alveolar proteinosis · score 0.52
- interstitial lung disease · score 0.51
- pulmonary alveolar proteinosis · score 0.44
- newborn respiratory distress syndrome · score 0.37
- Respiratory distress · score 0.27
- genetic disorder · score 0.27
- brain-lung-thyroid syndrome · score 0.27
- Generalized hypotonia · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11686-F1 | alphafold | PREDICTED | 70.09 | — |
Amino-acid sequence (197 residues)
MDVGSKEVLM ESPPDYSAAP RGRFGIPCCP VHLKRLLIVV VVVVLIVVVI VGALLMGLHM SQKHTEMVLE MSIGAPEAQQ RLALSEHLVT TATFSIGSTG LVVYDYQQLL IAYKPAPGTC CYIMKIAPES IPSLEALTRK VHNFQMECSL QAKPAVPTSK LGQAEGRDAG SAPSGGDPAF LGMAVSTLCG EVPLYYI
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