Alcohol dehydrogenase class-3 (ADH5)

About Alcohol dehydrogenase class-3

Alcohol dehydrogenase class-3 (ADH5) is a protein from Homo sapiens identified by UniProt accession P11766, 374 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.

Target properties

Protein name	Alcohol dehydrogenase class-3
UniProt accession	P11766
Gene	ADH5
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (153)

Diseases linked to this target (Open Targets).

AMED syndrome, digenic · score 0.56
blood protein measurement · score 0.35
sex hormone-binding globulin measurement · score 0.33
testosterone measurement · score 0.33
aspartate aminotransferase measurement · score 0.32
alcohol consumption measurement · score 0.29
neuroinflammatory disorder · score 0.22
high density lipoprotein cholesterol measurement · score 0.21
Microcephaly · score 0.18
Intellectual disability · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11766-F1	alphafold	PREDICTED	98.09	—

Amino-acid sequence (374 residues)

MANEVIKCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKII ATAVCHTDAY TLSGADPEGC FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC KFCLNPKTNL CQKIRVTQGK GLMPDGTSRF TCKGKTILHY MGTSTFSEYT VVADISVAKI DPLAPLDKVC LLGCGISTGY GAAVNTAKLE PGSVCAVFGL GGVGLAVIMG CKVAGASRII GVDINKDKFA RAKEFGATEC INPQDFSKPI QEVLIEMTDG GVDYSFECIG NVKVMRAALE ACHKGWGVSV VVGVAASGEE IATRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTHNL SFDEINKAFE LMHSGKSIRT VVKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards