Serine/threonine-protein kinase H1 (PSKH1)

About Serine/threonine-protein kinase H1

Serine/threonine-protein kinase H1 (PSKH1) is a protein from Homo sapiens identified by UniProt accession P11801, 424 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase H1
UniProt accession	P11801
Gene	PSKH1
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.37
lysosomal storage disease · score 0.37
neurodegenerative disease · score 0.37
Alzheimer disease · score 0.37
Parkinson disease · score 0.37
high density lipoprotein cholesterol measurement · score 0.30
apolipoprotein A 1 measurement · score 0.26
hemoglobin measurement · score 0.23
appendicular lean mass · score 0.22
alcohol drinking · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11801-F1	alphafold	PREDICTED	74.63	—

Amino-acid sequence (424 residues)

MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPVKA GFPAASQYAH PCPGPPTAGH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ QYNG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards