Cyclin-dependent kinase 4 (CDK4)

About Cyclin-dependent kinase 4

Cyclin-dependent kinase 4 (CDK4) is a protein from Homo sapiens identified by UniProt accession P11802, 303 residues long. MolForge cross-references it against 0 known binders and 929 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 4
UniProt accession	P11802
Gene	CDK4
Organism	Homo sapiens
Length	303 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (12)

DrugCentral-linked approved drugs that act on this protein.

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11802-F1	alphafold	PREDICTED	86.81	—

Amino-acid sequence (303 residues)

MATSRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGGGGGGLP ISTVREVALL RRLEAFEHPN VVRLMDVCAT SRTDREIKVT LVFEHVDQDL RTYLDKAPPP GLPAETIKDL MRQFLRGLDF LHANCIVHRD LKPENILVTS GGTVKLADFG LARIYSYQMA LTPVVVTLWY RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR DVSLPRGAFP PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISAFRAL QHSYLHKDEG NPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards