About Gamma-crystallin A
Gamma-crystallin A (CRYGA) is a protein
from Homo sapiens identified by UniProt accession
P11844, 174 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Gamma-crystallin A |
|---|
| UniProt accession | P11844 |
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| Gene | CRYGA |
|---|
| Organism | Homo sapiens |
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| Length | 174 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (110)
Diseases linked to this target (Open Targets).
- early-onset non-syndromic cataract · score 0.11
- cataract · score 0.11
- Posterior polar cataract · score 0.11
- Cataract-microcornea syndrome · score 0.10
- Cataract with Y-shaped suture opacities · score 0.10
- Partial congenital cataract · score 0.10
- isolated ectopia lentis · score 0.10
- Total congenital cataract · score 0.10
- hereditary hyperferritinemia with congenital cataracts · score 0.10
- Anterior polar cataract · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11844-F1 | alphafold | PREDICTED | 96.14 | — |
Amino-acid sequence (174 residues)
MGKITFYEDR DFQGRCYNCI SDCPNLRVYF SRCNSIRVDS GCWMLYERPN YQGHQYFLRR GKYPDYQHWM GLSDSVQSCR IIPHTSSHKL RLYERDDYRG LMSELTDDCA CVPELFRLPE IYSLHVLEGC WVLYEMPNYR GRQYLLRPGD YRRYHDWGGA DAKVGSLRRV TDLY
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