Ribose-phosphate pyrophosphokinase 2 (PRPS2)

About Ribose-phosphate pyrophosphokinase 2

Ribose-phosphate pyrophosphokinase 2 (PRPS2) is a protein from Homo sapiens identified by UniProt accession P11908, 318 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Ribose-phosphate pyrophosphokinase 2
UniProt accession	P11908
Gene	PRPS2
Organism	Homo sapiens
Length	318 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
acute lymphoblastic leukemia · score 0.08
tuberculosis · score 0.06
cervical squamous intraepithelial neoplasia · score 0.05
Chronic mucocutaneous candidosis · score 0.05
immune deficiency, familial variable · score 0.05
hyper-IgM syndrome type 3 · score 0.04
selective IgA deficiency disease · score 0.04
Sertoli Cell-Only Syndrome · score 0.04
hyper-IgM syndrome type 2 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11908-F1	alphafold	PREDICTED	95.31	—

Amino-acid sequence (318 residues)

MPNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG EDVYIIQSGC GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA VLQWIRENIA EWKNCIIVSP DAGGAKRVTS IADRLNVEFA LIHKERKKAN EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATKVYAILTH GIFSGPAISR INNAAFEAVV VTNTIPQEDK MKHCTKIQVI DISMILAEAI RRTHNGESVS YLFSHVPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards