About B-cell antigen receptor complex-associated protein alpha chain
B-cell antigen receptor complex-associated protein alpha chain (CD79A) is a protein
from Homo sapiens identified by UniProt accession
P11912, 226 residues long.
MolForge cross-references it against 0 known binders and
1,920 disease associations.
Target properties
| Protein name | B-cell antigen receptor complex-associated protein alpha chain |
|---|
| UniProt accession | P11912 |
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| Gene | CD79A |
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| Organism | Homo sapiens |
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| Length | 226 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (1920)
Diseases linked to this target (Open Targets).
- isolated agammaglobulinemia · score 0.61
- agammaglobulinemia · score 0.47
- diffuse large B-cell lymphoma · score 0.37
- autosomal agammaglobulinemia · score 0.37
- colorectal adenocarcinoma · score 0.37
- gliomatosis cerebri · score 0.37
- cutaneous melanoma · score 0.37
- chronic lymphocytic leukemia · score 0.30
- esophageal squamous cell carcinoma · score 0.30
- esophageal adenocarcinoma · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11912-F1 | alphafold | PREDICTED | 77.09 | — |
Amino-acid sequence (226 residues)
MPGGPGVLQA LPATIFLLFL LSAVYLGPGC QALWMHKVPA SLMVSLGEDA HFQCPHNSSN NANVTWWRVL HGNYTWPPEF LGPGEDPNGT LIIQNVNKSH GGIYVCRVQE GNESYQQSCG TYLRVRQPPP RPFLDMGEGT KNRIITAEGI ILLFCAVVPG TLLLFRKRWQ NEKLGLDAGD EYEDENLYEG LNLDDCSMYE DISRGLQGTY QDVGSLNIGD VQLEKP
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