About Polyadenylate-binding protein 1
Polyadenylate-binding protein 1 (PABPC1) is a protein
from Homo sapiens identified by UniProt accession
P11940, 636 residues long.
MolForge cross-references it against 0 known binders and
241 disease associations.
Target properties
| Protein name | Polyadenylate-binding protein 1 |
|---|
| UniProt accession | P11940 |
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| Gene | PABPC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 636 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (241)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.48
- Global developmental delay · score 0.47
- Atypical behavior · score 0.46
- Seizure · score 0.46
- Expressive language delay · score 0.46
- neurodegenerative disease · score 0.46
- hepatocellular carcinoma · score 0.42
- multiple myeloma · score 0.42
- calcium measurement · score 0.29
- differentiated thyroid carcinoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11940-F1 | alphafold | PREDICTED | 77.39 | — |
Amino-acid sequence (636 residues)
MNPSAPSYPM ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDMITRR SLGYAYVNFQ QPADAERALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY GFVHFETQEA AERAIEKMNG MLLNDRKVFV GRFKSRKERE AELGARAKEF TNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRKF EQMKQDRITR YQGVNLYVKN LDDGIDDERL RKEFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT KPLYVALAQR KEERQAHLTN QYMQRMASVR AVPNPVINPY QPAPPSGYFM AAIPQTQNRA AYYPPSQIAQ LRPSPRWTAQ GARPHPFQNM PGAIRPAAPR PPFSTMRPAS SQVPRVMSTQ RVANTSTQTM GPRPAAAAAA ATPAVRTVPQ YKYAAGVRNP QQHLNAQPQV TMQQPAVHVQ GQEPLTASML ASAPPQEQKQ MLGERLFPLI QAMHPTLAGK ITGMLLEIDN SELLHMLESP ESLRSKVDEA VAVLQAHQAK EAAQKAVNSA TGVPTV
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