DNA sliding clamp PCNA (PCNA)

About DNA sliding clamp PCNA

DNA sliding clamp PCNA (PCNA) is a protein from Homo sapiens identified by UniProt accession P12004, 261 residues long. MolForge cross-references it against 0 known binders and 1,108 disease associations.

Target properties

Protein name	DNA sliding clamp PCNA
UniProt accession	P12004
Gene	PCNA
Organism	Homo sapiens
Length	261 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1108)

Diseases linked to this target (Open Targets).

ataxia-telangiectasia-like disorder · score 0.30
body height · score 0.24
lung adenocarcinoma · score 0.24
gastric adenocarcinoma · score 0.24
neurodegenerative disease · score 0.19
neoplasm · score 0.11
oral squamous cell carcinoma · score 0.10
non-small cell lung carcinoma · score 0.10
clear cell renal carcinoma · score 0.10
esophageal squamous cell carcinoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12004-F1	alphafold	PREDICTED	94.33	—

Amino-acid sequence (261 residues)

MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK IADMGHLKYY LAPKIEDEEG S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards