Immunoglobulin iota chain (VPREB1)

About Immunoglobulin iota chain

Immunoglobulin iota chain (VPREB1) is a protein from Homo sapiens identified by UniProt accession P12018, 145 residues long. MolForge cross-references it against 0 known binders and 195 disease associations.

Target properties

Protein name	Immunoglobulin iota chain
UniProt accession	P12018
Gene	VPREB1
Organism	Homo sapiens
Length	145 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (195)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.38
neurodegenerative disease · score 0.36
Myopia · score 0.30
age at onset · score 0.30
testosterone measurement · score 0.30
visual perception measurement · score 0.26
glioblastoma multiforme · score 0.18
infection · score 0.11
infect · score 0.11
multiple myeloma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12018-F1	alphafold	PREDICTED	87.84	—

Amino-acid sequence (145 residues)

MSWAPVLLML FVYCTGCGPQ PVLHQPPAMS SALGTTIRLT CTLRNDHDIG VYSVYWYQQR PGHPPRFLLR YFSQSDKSQG PQVPPRFSGS KDVARNRGYL SISELQPEDE AMYYCAMGAR SSEKEERERE WEEEMEPTAA RTRVP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards