About Keratin, type II cytoskeletal 3
Keratin, type II cytoskeletal 3 (KRT3) is a protein
from Homo sapiens identified by UniProt accession
P12035, 628 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 3 |
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| UniProt accession | P12035 |
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| Gene | KRT3 |
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| Organism | Homo sapiens |
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| Length | 628 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- corneal dystrophy, Meesmann, 2 · score 0.69
- Meesmann corneal dystrophy · score 0.60
- clear cell renal carcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.14
- congenital hereditary endothelial dystrophy of cornea · score 0.11
- low grade glioma · score 0.11
- hepatocellular carcinoma · score 0.06
- esophageal adenocarcinoma · score 0.04
- central nervous system cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12035-F1 | alphafold | PREDICTED | 63.36 | — |
Amino-acid sequence (628 residues)
MSRQASKTSG GGSQGFSGRS AVVSGSSRMS CVAHSGGAGG GAYGFRSGAG GFGSRSLYNL GGNKSISISV AAGGSRAGGF GGGRSSCAFA GGYGGGFGSG YGGGFGGGFG GGRGMGGGFG GAGGFGGAGG FGGAGGFGGP GGFGGSGGFG GPGSLGSPGG FGPGGFPGGI QEVTINQSLL QPLNVEIDPQ IGQVKAQERE QIKTLNNKFA SFIDKVRFLE QQNKVLETKW NLLQQQGTSS ISGTNNLEPL FENHINYLRS YLDNILGERG RLDSELKNME DLVEDFKKKY EDEINKRTAA ENEFVTLKKD VDSAYMNKVE LQAKVDALID EIDFLRTLYD AELSQMQSHI SDTSVVLSMD NNRSLDLDSI IAEVRAQYED IAQRSKAEAE ALYQTKLGEL QTTAGRHGDD LRNTKSEIIE LNRMIQRLRA EIEGVKKQNA NLQTAIAEAE QHGEMALKDA NAKLQELQAA LQQAKDDLAR LLRDYQELMN VKLALDVEIA TYRKLLEGEE YRMSGECPSA VSISVVSSST TSASAGGYGG GYGGGMGGGL GGGFSAGGGS GSGFGRGGGG GIGGGFGGGS SGFSGGSGFG SISGARYGVS GGGFSSASNR GGSIKFSQSS QSSQRYSR
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