Cytochrome c oxidase subunit 6A1, mitochondrial…

About Cytochrome c oxidase subunit 6A1, mitochondrial

Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1) is a protein from Homo sapiens identified by UniProt accession P12074, 109 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Cytochrome c oxidase subunit 6A1, mitochondrial
UniProt accession	P12074
Gene	COX6A1
Organism	Homo sapiens
Length	109 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

Charcot-Marie-Tooth disease recessive intermediate D · score 0.72
neurodegenerative disease · score 0.46
peripheral neuropathy · score 0.26
endometrial cancer · score 0.18
body height · score 0.18
body mass index · score 0.17
mean corpuscular hemoglobin · score 0.14
body weight · score 0.14
urinary bladder cancer · score 0.12
reticulocyte count · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12074-F1	alphafold	PREDICTED	82.97	—

Amino-acid sequence (109 residues)

MAVVGVSSVS RLLGRSRPQL GRPMSSGAHG EEGSARMWKT LTFFVALPGV AVSMLNVYLK SHHGEHERPE FIAYPHLRIR TKPFPWGDGN HTLFHNPHVN PLPTGYEDE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1)