Histidine--tRNA ligase, cytoplasmic (HARS1)

About Histidine--tRNA ligase, cytoplasmic

Histidine--tRNA ligase, cytoplasmic (HARS1) is a protein from Homo sapiens identified by UniProt accession P12081, 509 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Histidine--tRNA ligase, cytoplasmic
UniProt accession	P12081
Gene	HARS1
Organism	Homo sapiens
Length	509 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

autosomal dominant Charcot-Marie-Tooth disease type 2W · score 0.77
Usher syndrome type 3B · score 0.56
spastic ataxia · score 0.51
Charcot-Marie-Tooth disease type 2 · score 0.50
Intellectual disability · score 0.48
Dysarthria · score 0.48
peripheral neuropathy · score 0.45
essential tremor · score 0.43
Hammer Toe Syndrome · score 0.43
Oculomotor apraxia · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12081-F1	alphafold	PREDICTED	91.81	—

Amino-acid sequence (509 residues)

MAERAALEEL VKLQGERVRG LKQQKASAEL IEEEVAKLLK LKAQLGPDES KQKFVLKTPK GTRDYSPRQM AVREKVFDVI IRCFKRHGAE VIDTPVFELK ETLMGKYGED SKLIYDLKDQ GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG NFDPMIPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVSDSK FRTICSSVDK LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYEAVL LQTPAQAGEE PLGVGSVAAG GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKIRTTETQ VLVASAQKKL LEERLKLVSE LWDAGIKAEL LYKKNPKLLN QLQYCEEAGI PLVAIIGEQE LKDGVIKLRS VTSREEVDVR REDLVEEIKR RTGQPLCIC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards