ADP/ATP translocase 1 (SLC25A4)

About ADP/ATP translocase 1

ADP/ATP translocase 1 (SLC25A4) is a protein from Homo sapiens identified by UniProt accession P12235, 298 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (167)

Diseases linked to this target (Open Targets).

• mitochondrial DNA depletion syndrome 12B (cardiomyopathic type), autosomal recessive · score 0.78
• progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2 · score 0.78
• mitochondrial DNA depletion syndrome 12A (cardiomyopathic type), autosomal dominant · score 0.74
• Congenital cataract - hypertrophic cardiomyopathy - mitochondrial myopathy · score 0.71
• mitochondrial disease · score 0.57
• neurodegenerative disease · score 0.53
• Fontaine progeroid syndrome · score 0.46
• hypertrophic cardiomyopathy · score 0.46
• genetic disorder · score 0.41
• progressive external ophthalmoplegia with mitochondrial DNA deletions · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Amino-acid sequence (298 residues)

External references