About Inosine-5'-monophosphate dehydrogenase 2
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is a protein
from Homo sapiens identified by UniProt accession
P12268, 514 residues long.
MolForge cross-references it against 0 known binders and
287 disease associations.
Target properties
| Protein name | Inosine-5'-monophosphate dehydrogenase 2 |
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| UniProt accession | P12268 |
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| Gene | IMPDH2 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (287)
Diseases linked to this target (Open Targets).
- acute graft vs. host disease · score 0.58
- lupus nephritis · score 0.58
- chronic kidney disease · score 0.58
- cytomegalovirus infection · score 0.56
- chronic renal failure syndrome · score 0.54
- systemic lupus erythematosus · score 0.54
- nephrotic syndrome · score 0.53
- adult acute lymphoblastic leukemia · score 0.53
- membranous glomerulonephritis · score 0.52
- cardiovascular disease · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12268-F1 | alphafold | PREDICTED | 92.12 | — |
Amino-acid sequence (514 residues)
MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDCFLEEIMT KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA KKQLLCGAAI GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KDKYPNLQVI GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF
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