Parathyroid hormone-related protein (PTHLH)

About Parathyroid hormone-related protein

Parathyroid hormone-related protein (PTHLH) is a protein from Homo sapiens identified by UniProt accession P12272, 177 residues long. MolForge cross-references it against 0 known binders and 919 disease associations.

Target properties

Protein name	Parathyroid hormone-related protein
UniProt accession	P12272
Gene	PTHLH
Organism	Homo sapiens
Length	177 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (919)

Diseases linked to this target (Open Targets).

brachydactyly type E · score 0.59
body height · score 0.48
breast carcinoma · score 0.45
hair shape measurement · score 0.39
balding measurement · score 0.38
protein measurement · score 0.37
genetic disorder · score 0.32
BMI-adjusted waist-hip ratio · score 0.32
breast size · score 0.31
breast cancer · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12272-F1	alphafold	PREDICTED	62.88	—

Amino-acid sequence (177 residues)

MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSRRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards