About Prolactin-inducible protein
Prolactin-inducible protein (PIP) is a protein
from Homo sapiens identified by UniProt accession
P12273, 146 residues long.
MolForge cross-references it against 0 known binders and
177 disease associations.
Target properties
| Protein name | Prolactin-inducible protein |
|---|
| UniProt accession | P12273 |
|---|
| Gene | PIP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 146 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (177)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- blood protein measurement · score 0.29
- sebaceous of Jadassohn nevus · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- neoplasm · score 0.06
- Spinal cord injury · score 0.05
- breast carcinoma · score 0.05
- pentosuria · score 0.05
- triple-negative breast cancer · score 0.04
- inflammatory bowel disease 30 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12273-F1 | alphafold | PREDICTED | 89.68 | — |
Amino-acid sequence (146 residues)
MRLLQLLFRA SPATLLLVLC LQLGANKAQD NTRKIIIKNF DIPKSVRPND EVTAVLAVQT ELKECMVVKT YLISSIPLQG AFNYKYTACL CDDNPKTFYW DFYTNRTVQI AAVVDVIREL GICPDDAAVI PIKNNRFYTI EILKVE
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