Creatine kinase B-type (CKB)

About Creatine kinase B-type

Creatine kinase B-type (CKB) is a protein from Homo sapiens identified by UniProt accession P12277, 381 residues long. MolForge cross-references it against 0 known binders and 269 disease associations.

Target properties

Protein name	Creatine kinase B-type
UniProt accession	P12277
Gene	CKB
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (269)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
body mass index · score 0.32
intelligence · score 0.31
vitamin D measurement · score 0.26
type 2 diabetes mellitus · score 0.25
hair color · score 0.23
body height · score 0.20
pancreatic carcinoma · score 0.19
reticulocyte count · score 0.19
hair colour measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P12277-F1	alphafold	PREDICTED	95.46	—

Amino-acid sequence (381 residues)

MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG FTLDDVIQTG VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY KPSDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM QKGGNMKEVF TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards