About High affinity immunoglobulin gamma Fc receptor I
High affinity immunoglobulin gamma Fc receptor I (FCGR1A) is a protein
from Homo sapiens identified by UniProt accession
P12314, 374 residues long.
MolForge cross-references it against 0 known binders and
407 disease associations.
Target properties
| Protein name | High affinity immunoglobulin gamma Fc receptor I |
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| UniProt accession | P12314 |
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| Gene | FCGR1A |
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| Organism | Homo sapiens |
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| Length | 374 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (407)
Diseases linked to this target (Open Targets).
- viral disease · score 0.38
- influenza · score 0.37
- cutaneous Leishmaniasis · score 0.37
- blood protein measurement · score 0.29
- neurodegenerative disease · score 0.26
- endometrial cancer · score 0.23
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.21
- inflammatory bowel disease · score 0.16
- monocyte count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12314-F1 | alphafold | PREDICTED | 85.12 | — |
Amino-acid sequence (374 residues)
MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFTEGEPL ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG ISVTVKELFP APVLNASVTS PLLEGNLVTL SCETKLLLQR PGLQLYFSFY MGSKTLRGRN TSSEYQILTA RREDSGLYWC EAATEDGNVL KRSPELELQV LGLQLPTPVW FHVLFYLAVG IMFLVNTVLW VTIRKELKRK KKWDLEISLD SGHEKKVISS LQEDRHLEEE LKCQEQKEEQ LQEGVHRKEP QGAT
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