About Low affinity immunoglobulin gamma Fc region receptor II-a
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) is a protein
from Homo sapiens identified by UniProt accession
P12318, 317 residues long.
MolForge cross-references it against 0 known binders and
909 disease associations.
Target properties
| Protein name | Low affinity immunoglobulin gamma Fc region receptor II-a |
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| UniProt accession | P12318 |
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| Gene | FCGR2A |
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| Organism | Homo sapiens |
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| Length | 317 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (909)
Diseases linked to this target (Open Targets).
- ulcerative colitis · score 0.45
- inflammatory bowel disease · score 0.45
- blood protein measurement · score 0.44
- systemic lupus erythematosus · score 0.43
- myeloid white cell count · score 0.37
- cutaneous Leishmaniasis · score 0.37
- basophil count · score 0.36
- ankylosing spondylitis · score 0.36
- mucocutaneous lymph node syndrome · score 0.36
- basophil percentage of leukocytes · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12318-F1 | alphafold | PREDICTED | 76.93 | — |
Amino-acid sequence (317 residues)
MTMETQMSQN VCPRNLWLLQ PLTVLLLLAS ADSQAAAPPK AVLKLEPPWI NVLQEDSVTL TCQGARSPES DSIQWFHNGN LIPTHTQPSY RFKANNNDSG EYTCQTGQTS LSDPVHLTVL SEWLVLQTPH LEFQEGETIM LRCHSWKDKP LVKVTFFQNG KSQKFSHLDP TFSIPQANHS HSGDYHCTGN IGYTLFSSKP VTITVQVPSM GSSSPMGIIV AVVIATAVAA IVAAVVALIY CRKKRISANS TDPVKAAQFE PPGRQMIAIR KRQLEETNND YETADGGYMT LNPRAPTDDD KNIYLTLPPN DHVNSNN
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